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Tumor necrosis factor alpha-mediated inflammation and remodeling of the extracellular matrix underlies aortic stiffening induced by the common chemotherapeutic agent doxorubicin
Aortic stiffening is a major independent risk factor for cardiovascular diseases, kidney dysfunction and cognitive impairment. Doxorubicin (DOXO) chemotherapy-treated cancer survivors have greater aortic stiffness relative to healthy controls, but the mechanisms by which DOXO induces arterial stiffe...
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| Publicado no: | Hypertension |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8035245/ https://ncbi.nlm.nih.gov/pubmed/33719511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.120.16759 |
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