DOCK7 protects against replication stress by promoting RPA stability on chromatin

RPA is a critical factor for DNA replication and replication stress response. Surprisingly, we found that chromatin RPA stability is tightly regulated. We report that the GDP/GTP exchange factor DOCK7 acts as a critical replication stress regulator to promote RPA stability on chromatin. DOCK7 is pho...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Gao, Ming, Guo, Guijie, Huang, Jinzhou, Hou, Xiaonan, Ham, Hyoungjun, Kim, Wootae, Zhao, Fei, Tu, Xinyi, Zhou, Qin, Zhang, Chao, Zhu, Qian, Liu, Jiaqi, Yan, Yuanliang, Xu, Zhijie, Yin, Ping, Luo, Kuntian, Weroha, John, Deng, Min, Billadeau, Daniel D, Lou, Zhenkun
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034614/
https://ncbi.nlm.nih.gov/pubmed/33704464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab134
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