Differential Therapeutic Effects of FXR Activation, sEH Inhibition, and Dual FXR/sEH Modulation in NASH in Diet-Induced Obese Mice

[Image: see text] Nonalcoholic fatty liver disease (NAFLD) is an epidemic chronic liver disease and may progress over nonalcoholic steatohepatitis (NASH) to liver cirrhosis and hepatocellular carcinoma. The multiple metabolic, environmental, and genetic factors that are involved in NAFLD/NASH pathog...

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Bibliografiske detaljer
Udgivet i:ACS Pharmacol Transl Sci
Main Authors: Helmstädter, Moritz, Schmidt, Jurema, Kaiser, Astrid, Weizel, Lilia, Proschak, Ewgenij, Merk, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033765/
https://ncbi.nlm.nih.gov/pubmed/33860214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00041
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