A New FXR Ligand Chemotype with Agonist/Antagonist Switch

[Image: see text] Therapeutic modulation of the bile acid-sensing transcription factor farnesoid X receptor (FXR) is an appealing strategy to counteract hepatic and metabolic diseases. Despite the availability of several highly potent FXR agonists structural diversity of FXR modulators is limited, a...

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Udgivet i:ACS Med Chem Lett
Main Authors: Helmstädter, Moritz, Vietor, Jan, Sommer, Jana, Schierle, Simone, Willems, Sabine, Kaiser, Astrid, Schmidt, Jurema, Merk, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883470/
https://ncbi.nlm.nih.gov/pubmed/33603974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00647
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