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A New FXR Ligand Chemotype with Agonist/Antagonist Switch
[Image: see text] Therapeutic modulation of the bile acid-sensing transcription factor farnesoid X receptor (FXR) is an appealing strategy to counteract hepatic and metabolic diseases. Despite the availability of several highly potent FXR agonists structural diversity of FXR modulators is limited, a...
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| 發表在: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2021
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7883470/ https://ncbi.nlm.nih.gov/pubmed/33603974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00647 |
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