F-aza-T-dCyd (NSC801845), a novel cytidine analog, in comparative cell culture and xenograft studies with the clinical candidates T-dCyd, F-T-dCyd and aza-T-dCyd

Herein 5-Aza-4’-thio-2’-β-fluoro-2’-deoxycytidine (F-aza-T-dCyd, NSC801845), a novel cytidine analog, is first disclosed and compared with T-dCyd, F-T-dCyd and aza-T-dCyd in cell culture and mouse xenograft studies in HCT-116 human colon carcinoma, OVCAR3 human ovarian carcinoma, NCI-H23 human NSCLC...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Morris, Joel, Wishka, Donn G., Lopez, Omar D., Rudchenko, Vladimir, Huang, Guangfei, Hoffman, Sierra N., Borgel, Suzanne, Georgius, Kyle, Carter, John, Stotler, Howard, Kunkel, Mark W., Collins, Jerry M., Hollingshead, Melinda G., Teicher, Beverly A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8030693/
https://ncbi.nlm.nih.gov/pubmed/33811149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0738
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