ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC

BACKGROUND: The nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills cancer cells and has the ability to perturb angiogenesis in vitro. In this study, the mechanism of action of ARC was further investigated by comparing in vitro and in vivo...

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Hauptverfasser: Stockwin, Luke H, Yu, Sherry X, Stotler, Howard, Hollingshead, Melinda G, Newton, Dianne L
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651907/
https://ncbi.nlm.nih.gov/pubmed/19232100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-63
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