Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis

Oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one) and several structurally related molecules have been shown to have in vitro and in vivo antiproliferative activity. This study aims to confirm and extend mechanistic studies by focusing on oxyphenisatin acetate (OXY, NSC 59687), the pro-drug of...

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Hlavní autoři: Morrison, Bethanie L, Mullendore, Michael E, Stockwin, Luke H, Borgel, Suzanne, Hollingshead, Melinda G, Newton, Dianne L
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2013
Témata:
Clinical Cancer Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892800/
https://ncbi.nlm.nih.gov/pubmed/24403234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.107
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