Proteomic Analysis of Nuclei isolated from cancer cell lines treated with Indenoisoquinoline NSC 724998, a novel Topoisomerase I Inhibitor

The indenoisoquinoline NSC724998 is a novel topoisomerase I (Top1) inhibitor entering Phase I clinical trials at the National Cancer Institute, USA. In this study, 2-D PAGE analysis was performed on nuclear lysates prepared from HCT-116 and A375 cells treated with 1µM NSC724998 for 24 hrs and the di...

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Hlavní autoři: Han, Bingnan, Stockwin, Luke H., Hancock, Chad, Yu, Sherry X., Hollingshead, Melinda G., Newton, Dianne L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917484/
https://ncbi.nlm.nih.gov/pubmed/20515076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr100194d
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