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Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
In connection with an ongoing investigation of indenoisoquinoline topoisomerase I (Top1) inhibitors as potential therapeutic agents, the intercalation pharmacophore possessing di(methoxy) and methylenedioxy substituents was held constant and new derivatives were synthesized with nitrogen heterocycle...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2526314/ https://ncbi.nlm.nih.gov/pubmed/17034134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060564z |
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