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Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles

In connection with an ongoing investigation of indenoisoquinoline topoisomerase I (Top1) inhibitors as potential therapeutic agents, the intercalation pharmacophore possessing di(methoxy) and methylenedioxy substituents was held constant and new derivatives were synthesized with nitrogen heterocycle...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Nagarajan, Muthukaman, Morrell, Andrew, Ioanoviciu, Alexandra, Antony, Smitha, Kohlhagen, Glenda, Hollingshead, Melinda, Pommier, Yves, Cushman, Mark
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2006
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526314/
https://ncbi.nlm.nih.gov/pubmed/17034134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060564z
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