Alcohol-, Diol-, and Carbohydrate-Substituted Indenoisoquinolines as Topoisomerase I Inhibitors: Investigating the Relationships Involving Stereochemistry, Hydrogen Bonding, and Biological Activity

The DNA-relaxing enzyme topoisomerase I (Top1) can be inhibited by heterocyclic compounds such as indolocarbazoles and indenoisoquinolines. Carbohydrate and hydroxyl-containing side chains are essential for the biological activity of indolocarbazoles. The current study investigated how similar funct...

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Detalhes bibliográficos
Main Authors: Peterson, Katherine E., Cinelli, Maris A., Morrell, Andrew E., Mehta, Akhil, Dexheimer, Thomas S., Agama, Keli, Antony, Smitha, Pommier, Yves, Cushman, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151643/
https://ncbi.nlm.nih.gov/pubmed/21710981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101338z
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