Loading...

A Systematic Study of Nitrated Indenoisoquinolines Reveals a Potent Topoisomerase I Inhibitor

The biological activity of indenoisoquinoline topoisomerase I inhibitors is significantly enhanced by nitration of the isoquinoline ring. In the present study, nitrated analogues were synthesized with the indenone ring substituted with methoxy groups to further explore a previously identified struct...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Morrell, Andrew, Antony, Smitha, Kohlhagen, Glenda, Pommier, Yves, Cushman, Mark
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526352/
https://ncbi.nlm.nih.gov/pubmed/17181156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm060974n
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!