Artemisinin dimer anti-cancer activity correlates with heme-catalyzed ROS generation and ER stress induction

Analogs of the malaria therapeutic, artemisinin, possess in vitro and in vivo anti-cancer activity. In this study, two dimeric artemisinins (NSC724910 and 735847) were studied to determine their mechanism of action. Dimers were >1000 fold more active than monomer and treatment was associated with...

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Detalhes bibliográficos
Main Authors: Stockwin, Luke H., Han, Bingnan, Yu, Sherry X., Hollingshead, Melinda G., ElSohly, Mahmoud A., Gul, Waseem, Slade, Desmond, Galal, Ahmed M., Newton, Dianne L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752979/
https://ncbi.nlm.nih.gov/pubmed/19533749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24496
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