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Artemisinin dimer anti-cancer activity correlates with heme-catalyzed ROS generation and ER stress induction
Analogs of the malaria therapeutic, artemisinin, possess in vitro and in vivo anti-cancer activity. In this study, two dimeric artemisinins (NSC724910 and 735847) were studied to determine their mechanism of action. Dimers were >1000 fold more active than monomer and treatment was associated with...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752979/ https://ncbi.nlm.nih.gov/pubmed/19533749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24496 |
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