Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers

Nine dihydroartemisinin acetal dimers (6–14) with diversely functionalized linker units were synthesized and tested for in vitro antiprotozoal, anticancer and antimicrobial activity. Compounds 6, 7 and 11 [IC(50): 3.0–6.7 nM (D6) and 4.2–5.9 nM (W2)] were appreciably more active than artemisinin (1)...

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Main Authors: Slade, Desmond, Galal, Ahmed M., Gul, Waseem, Radwan, Mohamed M., Ahmed, Safwat A., Khan, Shabana I., Tekwani, Babu L., Jacob, Melissa R., Ross, Samir A., ElSohly, Mahmoud A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824924/
https://ncbi.nlm.nih.gov/pubmed/19879765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.10.019
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