Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers

Nine dihydroartemisinin acetal dimers (6–14) with diversely functionalized linker units were synthesized and tested for in vitro antiprotozoal, anticancer and antimicrobial activity. Compounds 6, 7 and 11 [IC(50): 3.0–6.7 nM (D6) and 4.2–5.9 nM (W2)] were appreciably more active than artemisinin (1)...

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Detaylı Bibliyografya
Asıl Yazarlar: Slade, Desmond, Galal, Ahmed M., Gul, Waseem, Radwan, Mohamed M., Ahmed, Safwat A., Khan, Shabana I., Tekwani, Babu L., Jacob, Melissa R., Ross, Samir A., ElSohly, Mahmoud A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824924/
https://ncbi.nlm.nih.gov/pubmed/19879765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.10.019
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