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PKC phosphorylates HEXIM1 and regulates P-TEFb activity
The positive transcription elongation factor b (P-TEFb) regulates RNA polymerase II elongation. In cells, P-TEFb partitions between small active and larger inactive states. In the latter, HEXIM1 binds to 7SK snRNA and recruits as well as inactivates P-TEFb in the 7SK snRNP. Several stimuli can affec...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3467075/ https://ncbi.nlm.nih.gov/pubmed/22821562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks682 |
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