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Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb

Hexim1 is a cellular protein that associates with the positive transcription elongation factor b (P-TEFb) to regulate RNA polymerase II elongation of nascent mRNA transcripts. It directly binds to Cyclin T1 of P-TEFb and inhibits the kinase activity of Cdk9, leading to an arrest of transcription elo...

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Detalhes bibliográficos
Main Authors: Dames, Sonja A., Schönichen, André, Schulte, Antje, Barboric, Matjaz, Peterlin, B. Matija, Grzesiek, Stephan, Geyer, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955226/
https://ncbi.nlm.nih.gov/pubmed/17724342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701848104
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