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Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb
Hexim1 is a cellular protein that associates with the positive transcription elongation factor b (P-TEFb) to regulate RNA polymerase II elongation of nascent mRNA transcripts. It directly binds to Cyclin T1 of P-TEFb and inhibits the kinase activity of Cdk9, leading to an arrest of transcription elo...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1955226/ https://ncbi.nlm.nih.gov/pubmed/17724342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701848104 |
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