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Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb

Transcriptional elongation of most eukaryotic genes by RNA polymerase II requires the kinase activity of the positive transcription elongation factor b (P-TEFb). The catalytically active P-TEFb complex becomes inactive when sequestered into the large complex by the cooperative actions of 7SK snRNA a...

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Détails bibliographiques
Auteurs principaux: Blazek, Dalibor, Barboric, Matjaz, Kohoutek, Jiri, Oven, Irena, Peterlin, B. Matija
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1322273/
https://ncbi.nlm.nih.gov/pubmed/16377779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki997
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