F-aza-T-dCyd (NSC801845), a novel cytidine analog, in comparative cell culture and xenograft studies with the clinical candidates T-dCyd, F-T-dCyd and aza-T-dCyd

Herein 5-Aza-4’-thio-2’-β-fluoro-2’-deoxycytidine (F-aza-T-dCyd, NSC801845), a novel cytidine analog, is first disclosed and compared with T-dCyd, F-T-dCyd and aza-T-dCyd in cell culture and mouse xenograft studies in HCT-116 human colon carcinoma, OVCAR3 human ovarian carcinoma, NCI-H23 human NSCLC...

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Pubblicato in:Mol Cancer Ther
Autori principali: Morris, Joel, Wishka, Donn G., Lopez, Omar D., Rudchenko, Vladimir, Huang, Guangfei, Hoffman, Sierra N., Borgel, Suzanne, Georgius, Kyle, Carter, John, Stotler, Howard, Kunkel, Mark W., Collins, Jerry M., Hollingshead, Melinda G., Teicher, Beverly A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8030693/
https://ncbi.nlm.nih.gov/pubmed/33811149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0738
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