F-aza-T-dCyd (NSC801845), a novel cytidine analog, in comparative cell culture and xenograft studies with the clinical candidates T-dCyd, F-T-dCyd and aza-T-dCyd

Herein 5-Aza-4’-thio-2’-β-fluoro-2’-deoxycytidine (F-aza-T-dCyd, NSC801845), a novel cytidine analog, is first disclosed and compared with T-dCyd, F-T-dCyd and aza-T-dCyd in cell culture and mouse xenograft studies in HCT-116 human colon carcinoma, OVCAR3 human ovarian carcinoma, NCI-H23 human NSCLC...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Morris, Joel, Wishka, Donn G., Lopez, Omar D., Rudchenko, Vladimir, Huang, Guangfei, Hoffman, Sierra N., Borgel, Suzanne, Georgius, Kyle, Carter, John, Stotler, Howard, Kunkel, Mark W., Collins, Jerry M., Hollingshead, Melinda G., Teicher, Beverly A.
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8030693/
https://ncbi.nlm.nih.gov/pubmed/33811149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0738
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