Exploring the putative mechanism of allosteric modulations by mixed-action kappa/mu opioid receptor bitopic modulators

The modulation and selectivity mechanisms of seven mixed-action kappa opioid receptor (KOR)/mu opioid receptor (MOR) bitopic modulators were explored. Molecular modeling results indicated that the ‘message’ moiety of seven bitopic modulators shared the same binding mode with the orthosteric site of...

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Gepubliceerd in:Future Med Chem
Hoofdauteurs: Wang, Huiqun, Cao, Danni, Gillespie, James C, Mendez, Rolando E, Selley, Dana E, Liu-Chen, Lee-Yuan, Zhang, Yan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Newlands Press Ltd 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027703/
https://ncbi.nlm.nih.gov/pubmed/33590767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2020-0308
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