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A Universal Allosteric Mechanism for G Protein Activation.
G proteins play a central role in signal transduction and pharmacology. Signaling is initiated by cell-surface receptors, which promote GTP binding and the dissociation of Gα from the Gβγ subunits. Structural studies have revealed the molecular basis for subunit association with receptors, RGS prote...
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| Veröffentlicht in: | Mol Cell |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026646/ https://ncbi.nlm.nih.gov/pubmed/33636126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.02.002 |
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