The Ubiquitin Specific Protease USP18 Promotes Lipolysis, Fatty Acid Oxidation and Lung Cancer Growth

Ubiquitin specific protease18 (USP18), previously known as UBP43, is the Interferon-Stimulated Gene 15 (ISG15) deconjugase. USP18 removes ISG15 from substrate proteins. This study reports that USP18 null mice (versus wild-type mice) exhibited lower lipolysis rates, altered fat to body weight ratios...

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Bibliographic Details
Published in:Mol Cancer Res
Main Authors: Liu, Xi, Lu, Yun, Chen, Zibo, Liu, Xiuxia, Hu, Weiguo, Zheng, Lin, Chen, Yulong, Kurie, Jonathan M., Shi, Mi, Mustachio, Lisa Maria, Adresson, Thorkell, Fox, Stephen, Roszik, Jason, Kawakami, Masanori, Freemantle, Sarah, Dmitrovsky, Ethan
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026529/
https://ncbi.nlm.nih.gov/pubmed/33380466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0579
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