The Heme-regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

Anti-apoptotic MCL1 is one of the most frequently amplified genes in human cancers and elevated expression confers resistance to many therapeutics including the BH3-mimetic agents ABT-199 and ABT-263. The anti-malarial, dihydroartemisinin (DHA) translationally represses MCL-1 and synergizes with BH3...

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Pubblicato in:Mol Cancer Res
Autori principali: Smith, Kaitlyn H., Budhraja, Amit, Lynch, John, Roberts, Kathryn, Panetta, John C., Connelly, Jon P., Turnis, Meghan E., Pruett-Miller, Shondra M., Schuetz, John D., Mullighan, Charles G., Opferman, Joseph T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026502/
https://ncbi.nlm.nih.gov/pubmed/33288732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0586
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