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Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions
Myofibroblasts are the major cellular source of collagen, and their accumulation — via differentiation from fibroblasts and resistance to apoptosis — is a hallmark of tissue fibrosis. Clearance of myofibroblasts by dedifferentiation and restoration of apoptosis sensitivity has the potential to rever...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026183/ https://ncbi.nlm.nih.gov/pubmed/33561015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144799 |
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