Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions

Myofibroblasts are the major cellular source of collagen, and their accumulation — via differentiation from fibroblasts and resistance to apoptosis — is a hallmark of tissue fibrosis. Clearance of myofibroblasts by dedifferentiation and restoration of apoptosis sensitivity has the potential to rever...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Fortier, Sean M., Penke, Loka R., King, Dana, Pham, Tho X., Ligresti, Giovanni, Peters-Golden, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026183/
https://ncbi.nlm.nih.gov/pubmed/33561015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144799
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