Prostaglandin E(2) Inhibits α-Smooth Muscle Actin Transcription during Myofibroblast Differentiation via Distinct Mechanisms of Modulation of Serum Response Factor and Myocardin-related Transcription Factor-A

Differentiation of lung fibroblasts into contractile protein-expressing myofibroblasts by transforming growth factor-β1 (TGF-β1) is a critical event in the pathogenesis of pulmonary fibrosis. Transcription of the contractile protein α-smooth muscle actin (α-SMA) is mediated by the transcription fact...

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Autores principales: Penke, Loka R. K., Huang, Steven K., White, Eric S., Peters-Golden, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Gene Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059156/
https://ncbi.nlm.nih.gov/pubmed/24802754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558130
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