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Akt1 Mediates α-Smooth Muscle Actin Expression and Myofibroblast Differentiation via Myocardin and Serum Response Factor

Myofibroblast (MF) differentiation, marked by the de novo expression of smooth muscle α-actin (αSMA) stress fibers, plays a central role in wound healing and its persistence is a hallmark of fibrotic diseases. We have previously shown that Akt1 is necessary for wound healing through matrix regulatio...

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Bibliografiske detaljer
Main Authors: Abdalla, Maha, Goc, Anna, Segar, Lakshman, Somanath, Payaningal R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829193/
https://ncbi.nlm.nih.gov/pubmed/24106278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.504290
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