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p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling

Previous studies have demonstrated both synergistic and opposing effects of Akt and Mek1/2 in various cell functions and disease states. Furthermore, Akt has been reported to inhibit and activate cRaf/Mek pathway, suggesting that their mutual interaction and cooperation may be cell type, stimuli and...

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Publicat a:Biochim Biophys Acta
Autors principals: Goc, Anna, Sabbineni, Harika, Abdalla, Maha, Somanath, Payaningal R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428983/
https://ncbi.nlm.nih.gov/pubmed/25843685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.03.016
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