Distinct PKA regulatory subunits mediate PGE(2) inhibition of TGFβ-1-stimulated collagen I translation and myofibroblast differentiation

Prostaglandin E(2) (PGE(2)), via cAMP signaling, inhibits a variety of fibroblast functions relevant to fibrogenesis. Among these are their translation of collagen I protein and their differentiation to myofibroblasts. PKA is central to these actions, with cAMP binding to regulatory (R) subunits lea...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Wettlaufer, Scott H., Penke, L. Raghu, Okunishi, Katsuhide, Peters-Golden, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148086/
https://ncbi.nlm.nih.gov/pubmed/28729346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00131.2017
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