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Distinct PKA regulatory subunits mediate PGE(2) inhibition of TGFβ-1-stimulated collagen I translation and myofibroblast differentiation
Prostaglandin E(2) (PGE(2)), via cAMP signaling, inhibits a variety of fibroblast functions relevant to fibrogenesis. Among these are their translation of collagen I protein and their differentiation to myofibroblasts. PKA is central to these actions, with cAMP binding to regulatory (R) subunits lea...
Zapisane w:
| Wydane w: | Am J Physiol Lung Cell Mol Physiol |
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| Główni autorzy: | , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Physiological Society
2017
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6148086/ https://ncbi.nlm.nih.gov/pubmed/28729346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00131.2017 |
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