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Sex-dependent lifespan extension of Apc(Min/+) FAP mice by chronic mTOR inhibition

BACKGROUND: Apc(Min/+) mice model familial adenomatous polyposis (FAP), a disease that causes numerous colon polyps leading to colorectal cancer. We previously showed that chronic treatment of Apc(Min/+) females with the anti-aging drug, rapamycin, restored a normal lifespan through reduced polyposi...

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Podrobná bibliografie
Vydáno v:Aging Pathobiol Ther
Hlavní autoři: Parihar, Manish, Dodds, Sherry G., Javors, Marty, Strong, Randy, Hasty, Paul, Sharp, Zelton Dave
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026166/
https://ncbi.nlm.nih.gov/pubmed/33834178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.31491/apt.2020.12.039
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