Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I

The 7-azaindenoisoquinolines are cytotoxic topoisomerase I (Top1) inhibitors. Previously reported representatives bear a 3-nitro group. The present report documents the replacement of the potentially genotoxic 3-nitro group by 3-chloro and 3-fluoro substituents, resulting in compounds with high Top1...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Elsayed, Mohamed S. A., Su, Yafan, Wang, Ping, Sethi, Taresh, Agama, Keli, Ravji, Azhar, Redon, Christophe E., Kiselev, Evgeny, Horzmann, Katharine A., Freeman, Jennifer L., Pommier, Yves, Cushman, Mark
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025945/
https://ncbi.nlm.nih.gov/pubmed/28657311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01870
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