Synthesis and Biological Evaluation of New Fluorinated and Chlorinated Indenoisoquinoline Topoisomerase I Poisons

Fluorine and chlorine are metabolically stable, but generally less active replacements for a nitro group at the 3-position of indenoisoquinoline topoisomerase IB (Top1) poisons. A number of strategies were employed in the present investigation to enhance the Top1 inhibitory potencies and cancer cell...

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Pubblicato in:Bioorg Med Chem
Autori principali: Beck, Daniel E., Lv, Wei, Abdelmalak, Monica, Plescia, Caroline B., Agama, Keli, Marchand, Christophe, Pommier, Yves, Cushman, Mark
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789169/
https://ncbi.nlm.nih.gov/pubmed/26906474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.02.015
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