Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3-Nitro Toxicophore

3-Nitroindenoisoquinoline human topoisomerase IB (Top1) poisons have potent antiproliferative effects on cancer cells. The undesirable nitro toxicophore could hypothetically be replaced by other functional groups that would retain the desired biological activities and minimize potential safety risks...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Beck, Daniel E., Abdelmalak, Monica, Lv, Wei, Reddy, P. V. Narasimha, Tender, Gabrielle S., O’Neill, Elizaveta, Agama, Keli, Marchand, Christophe, Pommier, Yves, Cushman, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7753975/
https://ncbi.nlm.nih.gov/pubmed/25909279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00303
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