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Optimization of the Lactam Side Chain of 7-Azaindenoisoquinoline Topoisomerase I Inhibitors and Mechanism of Action Studies in Cancer Cells
[Image: see text] Optimization of the lactam ω-aminoalkyl substituents in a series of 7-azaindenoisoquinolines resulted in new anticancer agents with improved Top1 inhibitory potencies and cancer cell cytotoxicities. The new compounds 14–17 and 19 exhibited mean graph midpoint cytotoxicity (GI(50))...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American
Chemical
Society
2014
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983387/ https://ncbi.nlm.nih.gov/pubmed/24502276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401471v |
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