Optimization of the Lactam Side Chain of 7-Azaindenoisoquinoline Topoisomerase I Inhibitors and Mechanism of Action Studies in Cancer Cells

[Image: see text] Optimization of the lactam ω-aminoalkyl substituents in a series of 7-azaindenoisoquinolines resulted in new anticancer agents with improved Top1 inhibitory potencies and cancer cell cytotoxicities. The new compounds 14–17 and 19 exhibited mean graph midpoint cytotoxicity (GI(50))...

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Hlavní autoři: Kiselev, Evgeny, Sooryakumar, Dhriti, Agama, Keli, Cushman, Mark, Pommier, Yves
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983387/
https://ncbi.nlm.nih.gov/pubmed/24502276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401471v
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