Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer’s Disease

Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Chronic increase of brain nSMase2 activity and related exosome relea...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Šála, Michal, Hollinger, Kristen R., Thomas, Ajit G., Dash, Ranjeet P., Tallon, Carolyn, Veeravalli, Vijayabhaskar, Lovell, Lyndah, Kögler, Martin, Hřebabecký, Hubert, Procházková, Eliška, Nešuta, Ondřej, Donoghue, Amanda, Lam, Jenny, Rais, Rana, Rojas, Camilo, Slusher, Barbara S., Nencka, Radim
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025741/
https://ncbi.nlm.nih.gov/pubmed/32298582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00278
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