Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer’s Disease

Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Chronic increase of brain nSMase2 activity and related exosome relea...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Šála, Michal, Hollinger, Kristen R., Thomas, Ajit G., Dash, Ranjeet P., Tallon, Carolyn, Veeravalli, Vijayabhaskar, Lovell, Lyndah, Kögler, Martin, Hřebabecký, Hubert, Procházková, Eliška, Nešuta, Ondřej, Donoghue, Amanda, Lam, Jenny, Rais, Rana, Rojas, Camilo, Slusher, Barbara S., Nencka, Radim
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025741/
https://ncbi.nlm.nih.gov/pubmed/32298582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00278
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