Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and extracellular vesicles (EVs), both of which are d...

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Main Authors: Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-07-01
Serier:Neurobiology of Disease
Fag:
Neutral sphingomyelinase 2
Depression
Sleep
HIV
Extracellular vesicle
EcoHIV
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996122001267
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