Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and extracellular vesicles (EVs), both of which are d...

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Autori principali: Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2022-07-01
Serie:Neurobiology of Disease
Soggetti:
Neutral sphingomyelinase 2
Depression
Sleep
HIV
Extracellular vesicle
EcoHIV
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996122001267
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