Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and extracellular vesicles (EVs), both of which are d...

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Hlavní autoři: Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2022-07-01
Edice:Neurobiology of Disease
Témata:
Neutral sphingomyelinase 2
Depression
Sleep
HIV
Extracellular vesicle
EcoHIV
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0969996122001267
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