A novel and potent brain penetrant inhibitor of extracellular vesicle release

BACKGROUND AND PURPOSE: Extracellular vesicles (EVs) are constitutively shed from cells and released by various stimuli. Their protein and RNA cargo are modified by the stimulus, and in disease conditions can carry pathological cargo involved in disease progression. Neutral sphingomyelinase 2 (nSMas...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Rojas, Camilo, Sala, Michal, Thomas, Ajit G., Datta Chaudhuri, Amrita, Yoo, Seung‐Wan, Li, Zhigang, Dash, Ranjeet P., Rais, Rana, Haughey, Norman J., Nencka, Radim, Slusher, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780992/
https://ncbi.nlm.nih.gov/pubmed/31273753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14789
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