DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

Brain injury and inflammation induces a local release of extracellular vesicles (EVs) from astrocytes carrying proteins, RNAs, and microRNAs into the circulation. When these vesicles reach the liver, they stimulate the secretion of cytokines that mobilize peripheral immune cell infiltration into the...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Rojas, Camilo, Barnaeva, Elena, Thomas, Ajit G., Hu, Xin, Southall, Noel, Marugan, Juan, Chaudhuri, Amrita Datta, Yoo, Seung-Wan, Hin, Niyada, Stepanek, Ondrej, Wu, Ying, Zimmermann, Sarah C., Gadiano, Alexandra G., Tsukamoto, Takashi, Rais, Rana, Haughey, Norman, Ferrer, Marc, Slusher, Barbara S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286365/
https://ncbi.nlm.nih.gov/pubmed/30531925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36144-2
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