DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

Brain injury and inflammation induces a local release of extracellular vesicles (EVs) from astrocytes carrying proteins, RNAs, and microRNAs into the circulation. When these vesicles reach the liver, they stimulate the secretion of cytokines that mobilize peripheral immune cell infiltration into the...

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Publicado en:Sci Rep
Main Authors: Rojas, Camilo, Barnaeva, Elena, Thomas, Ajit G., Hu, Xin, Southall, Noel, Marugan, Juan, Chaudhuri, Amrita Datta, Yoo, Seung-Wan, Hin, Niyada, Stepanek, Ondrej, Wu, Ying, Zimmermann, Sarah C., Gadiano, Alexandra G., Tsukamoto, Takashi, Rais, Rana, Haughey, Norman, Ferrer, Marc, Slusher, Barbara S.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286365/
https://ncbi.nlm.nih.gov/pubmed/30531925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36144-2
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