A novel and potent brain penetrant inhibitor of extracellular vesicle release

BACKGROUND AND PURPOSE: Extracellular vesicles (EVs) are constitutively shed from cells and released by various stimuli. Their protein and RNA cargo are modified by the stimulus, and in disease conditions can carry pathological cargo involved in disease progression. Neutral sphingomyelinase 2 (nSMas...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Rojas, Camilo, Sala, Michal, Thomas, Ajit G., Datta Chaudhuri, Amrita, Yoo, Seung‐Wan, Li, Zhigang, Dash, Ranjeet P., Rais, Rana, Haughey, Norman J., Nencka, Radim, Slusher, Barbara
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6780992/
https://ncbi.nlm.nih.gov/pubmed/31273753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14789
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