Tumor-Targeted Delivery of 6-Diazo-5-oxo-l-norleucine (DON) Using Substituted Acetylated Lysine Prodrugs

6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist with robust anticancer efficacy; however, its therapeutic potential was hampered by its biodistribution and toxicity to normal tissues, specifically gastrointestinal (GI) tissues. To circumvent DON’s toxicity, we synthesized a series of tumo...

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Publicado en:J Med Chem
Autores principales: Tenora, Lukáš, Alt, Jesse, Dash, Ranjeet P., Gadiano, Alexandra J., Novotná, Kateřina, Veeravalli, Vijayabhaskar, Lam, Jenny, Kirkpatrick, Quinn R., Lemberg, Kathryn M., Majer, Pavel, Rais, Rana, Slusher, Barbara S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8025739/
https://ncbi.nlm.nih.gov/pubmed/30892035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b02009
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