Transglutaminase 2 Depletion Attenuates α-Synuclein Mediated Toxicity in Mice

α-Synuclein (α-Syn) is a key pathogenic protein in α-synucleinopathies including Parkinson disease (PD) and Dementia with Lewy Bodies. The aggregation of α-Syn is believed to be deleterious and a critical step leading to neuronal dysfunction and death. One of the factors that may contribute to the i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuroscience
Auteurs principaux: Zhang, Jie, Jasutkar, Hilary Grosso, Yan, Run, Woo, Jong-Min, Lee, Kang-Woo, Im, Joo-Young, Junn, Eunsung, Iismaa, Siiri E., Mouradian, M. Maral
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024061/
https://ncbi.nlm.nih.gov/pubmed/32502569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2020.05.047
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