Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen rec...

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Опубликовано в: :Mol Ther Nucleic Acids
Главные авторы: Corbin, Joshua M., Georgescu, Constantin, Wren, Jonathan D., Xu, Chao, Asch, Adam S., Ruiz-Echevarría, Maria J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2021
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022159/
https://ncbi.nlm.nih.gov/pubmed/33850637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.03.002
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