Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen rec...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Corbin, Joshua M., Georgescu, Constantin, Wren, Jonathan D., Xu, Chao, Asch, Adam S., Ruiz-Echevarría, Maria J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2021
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022159/
https://ncbi.nlm.nih.gov/pubmed/33850637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.03.002
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