Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen rec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther Nucleic Acids
Prif Awduron: Corbin, Joshua M., Georgescu, Constantin, Wren, Jonathan D., Xu, Chao, Asch, Adam S., Ruiz-Echevarría, Maria J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Gene & Cell Therapy 2021
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022159/
https://ncbi.nlm.nih.gov/pubmed/33850637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.03.002
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