Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells

Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen rec...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Corbin, Joshua M., Georgescu, Constantin, Wren, Jonathan D., Xu, Chao, Asch, Adam S., Ruiz-Echevarría, Maria J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022159/
https://ncbi.nlm.nih.gov/pubmed/33850637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.03.002
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