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Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN-amplified neuroblastoma
MYCN-amplified neuroblastoma is a lethal subset of pediatric cancer. MYCN drives numerous effects in the cell, including metabolic changes that are critical for oncogenesis. The understanding that both compensatory pathways and intrinsic redundancy in cell systems exists implies that the use of comb...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8020796/ https://ncbi.nlm.nih.gov/pubmed/33762304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009620118 |
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